A general approach is presented for creating polymer-gels that can recogniz
e and capture a target molecule by multiple-point interaction and that can
reversibly change their affinity to the target by more than one order of ma
gnitude. The polymers consist of majority monomers that make the gel revers
ibly swell and shrink and minority monomers that constitute multiple-point
adsorption centers for the target molecule, Multiple-point interaction is e
xperimentally proven by power Laws found between the affinity and the conce
ntration of the adsorbing monomers within the gels.