Centro-facial malignant granuloma is a syndrome that encompasses several co
nditions. Studies using immunolabeling and molecular biology techniques hav
e shown that T-cell lymphoma is among the causes of centro-facial malignant
granuloma. Six cases of centro-facial T-cell lymphoma in three men and thr
ee women aged 28 to 57 years (mean age, 39 years) were studied. The outcome
was favorable in two cases after chemotherapy and radiation therapy.