An efficient synthesis of chiral homophenylalanine derivatives via enantioselective hydrogenation

Authors
Li, XS Yeung, CH Chan, ASC Lee, DS Yang, TK
Citation
Xs. Li et al., An efficient synthesis of chiral homophenylalanine derivatives via enantioselective hydrogenation, TETRAHEDR-A, 10(20), 1999, pp. 3863-3867
Citations number
16
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
20
Year of publication
1999
Pages
3863 - 3867
Database
ISI
SICI code
0957-4166(19991015)10:20<3863:AESOCH>2.0.ZU;2-4
Abstract
Chiral homophenylalanine derivatives were synthesized via enantioselective hydrogenation of 5a and 5b catalyzed by rhodium complexes bearing chiral ph osphine and phosphinite legands. Enantiomeric excesses up to 96.2% were ach ieved when S-spiroOP(S-1) was used as a chiral ligand under 500 psi of H-2 pressure in acetone. (C) 1999 Elsevier Science Ltd. All rights reserved.