Enantioselective addition of organometallics to aldehydes using camphor derived chiral 1,4-aminoalcohols as ligands

Authors
Knollmuller, M Ferencic, M Gartner, P
Citation
M. Knollmuller et al., Enantioselective addition of organometallics to aldehydes using camphor derived chiral 1,4-aminoalcohols as ligands, TETRAHEDR-A, 10(20), 1999, pp. 3969-3975
Citations number
37
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
20
Year of publication
1999
Pages
3969 - 3975
Database
ISI
SICI code
0957-4166(19991015)10:20<3969:EAOOTA>2.0.ZU;2-D
Abstract
(+)-Camphor derived enantiomerically pure 1,4-aminoalcohols have been used as ligands in the addition reactions of n-BuLi and n-BuMgBr to benzaldehyde and in the reaction of diethylzinc with benzaldehyde and hexanal. All chir al secondary alcohols were obtained in good chemical yields and enantiosele ctivities were up to 87% ee in the addition of diethylzinc. (C) 1999 Elsevi er Science Ltd. All rights reserved.