S. Graf et al., Experimental and clinical validation of arterial diameter waveform and intimal media thickness obtained from B-mode ultrasound image processing, ULTRASOUN M, 25(9), 1999, pp. 1353-1363
A new automated computerized system (IoTEC(TM)) that assesses concomitantly
the instantaneous temporal arterial diameter and intimal media thickness (
IMT) obtained from B-mode ultrasound (US) images was validated by sonomicro
metry in sheep, by an echo-tracking system in humans, and by a Lucite phant
om in vitro. Differences between methods for diameter measurements did not
vary in any systematic way, with no significant differences in the lower fr
equency range. Ultrasonic measurements of the true phantom gap sizes showed
high correlation (r2 = 0.98,p < 0.001) with no systematic errors. Carotid
and femoral arteries in humans were strongly related between IoTEC(TM) and
echo-tracking device (r2 = 0.94 carotid; R2 = 0.88 femoral, p < 0.001), wit
h a Gaussian distribution of the errors. This new method showed high intra-
and interobserver repeatability of arterial diameter and IMT, allowing con
sistent characterization of arterial dynamics in humans. (C) 1999 World Fed
eration for Ultrasound in Medicine & Biology.