Disseminated blastomycosis in a rhesus monkey (Macaca mulatta)

An 8-year-old male rhesus monkey (Macaca mulatta) died following a 6-day il lness consisting of progressive depression, anorexia, labored abdominal bre athing, coughing, and tachypnea. Gross necropsy findings included severe mu ltifocal (miliary) granulomatous pneumonia, granulomatous splenitis, and mu ltifocal cerebral abscesses. Histologic examination revealed 10-15-mu m bro ad-based budding organisms within pyogranulomatous inflammatory lesions in the lung, tracheobronchial lymph node, brain, spleen, and liver. The distri bution of extrapulmonary lesions was intermediate between that described fo r dogs and that described for humans. These findings were consistent with b lastomycosis, which is previously unreported in nonhuman primates.