Nj. Bodsworth et al., THE EFFECT OF IMMUNIZATION WITH INACTIVATED HEPATITIS-A VACCINE ON THE CLINICAL COURSE OF HIV-1 INFECTION - 1-YEAR FOLLOW-UP, AIDS, 11(6), 1997, pp. 747-749
Objective: To determine the long-term safety of inactivated hepatitis
A virus (HAV) vaccine in men infected with HIV-1. Design: A 1-year pro
spective case-control study. Setting: Targeted primary care and sexual
ly transmitted diseases clinics. Patients: Ninety HIV-1-positive patie
nts who participated in an earlier efficacy study of HAV vaccination.
Controls: Ninety HIV-1-positive men, matched for CD4+ lymphocyte perce
ntage at baseline, who did not receive HAV vaccine. Intervention: All
cases were assigned to receive two intramuscular doses of 1440 enzyme-
linked immunosorbent assay units of inactivated HAV vaccine (Havrix) e
ither 1 or 6 months apart. Main outcome measures: Development of AIDS,
survival, and T-cell subsets after 1 year of follow-up. Results: No s
ignificant differences were seen between cases and control for the dev
elopment of AIDS (10.1 versus 10.7%), deaths (7.3 versus 7.6%) nor for
mean decline in circulating CD4+ lymphocyte count (125 versus 123x10(
6)/l) after 1 year. Conclusions: Vaccination against HAV appears to be
safe in the longer term for HIV-1-infected men.