Effects of inhaled fluticasone propionate on bone mass in children

The CUBA McCue ultrasound bone analyzer has been used to evaluate the effec t of fluticason propionate inhalation treatment on bone mass in children. I t reveals an obvious correlation between ulrasound bone parameters, and the cumulative inhaled dose and duration of therapy. The velocity of sound, ex pressing mainly bone density, seems to be an early ultrasound sign of the n egative bone response to treatment. Significant differences in the paramete rs were found between children after one year of therapy with cumulative do ses of 50-100 mg and controls. After a double cumulative dose taken over a period of two years significant worsening of the broadband ultrasound atten uation was recorded. Most important this examination reveals the architectu re state of the trabecular bone. With increasing doses of the drug or lengt h of treatment, both examinations attain very negative numbers.