Effect at short-term vitamin (folic acid, vitamins B-6 and B-12) administration on endothelial dysfunction induced by post-methionine load hyperhomocysteinemia

Authors
Chao, CL Chien, KL Lee, YT
Citation
Cl. Chao et al., Effect at short-term vitamin (folic acid, vitamins B-6 and B-12) administration on endothelial dysfunction induced by post-methionine load hyperhomocysteinemia, AM J CARD, 84(11), 1999, pp. 1359
Citations number
20
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
AMERICAN JOURNAL OF CARDIOLOGY
ISSN journal
00029149 → ACNP
Volume
84
Issue
11
Year of publication
1999
Database
ISI
SICI code
0002-9149(199912)84:11<1359:EASV(A>2.0.ZU;2-E
Abstract
This study showed that short-term vitamin administration effectively reduce d post-methionine load homocysteine levels and thereby ameliorated endothel ium-dependent flow-mediated vasodilation in 16 healthy adults. Post-methion ine load homocysteine levels decreased from 22.7 +/- 3.8 to 17.0 +/- 2.1 mu mol/L (p <0.001), and flow-mediated vasodilation after methionine load inc reased from 8.6 +/- 3.6% to 13.8 +/- 2.9% (p <0.001) after vitamin administ ration.