Nutrient Tasting and Signaling Mechanisms in the Gut I. Sensing of lipid by the intestinal mucosa

It is well recognized that lipid in the intestine is a potent inhibitor of gastric secretomotor function. Progress has been made in the identification of the "sensor" for lipid in the intestinal wall. Long-chain free fatty ac ids are the stimulus both for release of CCK and for the production of func tional effects. Long-chain triglyceride requires chylomicron formation for absorption, and there is strong evidence that the postabsorptive products o f long-chain triglyceride absorption, including chylomicrons and apolipopro teins, are involved in sensory transduction in the intestinal wall.