SYNTHESIS OF HOMOCHIRAL SYN AND ANTI-ALPHA-(HYDROXYETHYL)-GAMMA-BUTYROLACTONES VIA MICROBIAL REDUCTION

Authors
FANTIN G FOGAGNOLO M GIOVANNINI P MEDICI A PAGNOTTA E PEDRINI P TRINCONE A
Citation
G. Fantin et al., SYNTHESIS OF HOMOCHIRAL SYN AND ANTI-ALPHA-(HYDROXYETHYL)-GAMMA-BUTYROLACTONES VIA MICROBIAL REDUCTION, Tetrahedron : asymmetry, 5(9), 1994, pp. 1631-1634
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
5
Issue
9
Year of publication
1994
Pages
1631 - 1634
Database
ISI
SICI code
0957-4166(1994)5:9<1631:SOHSAA>2.0.ZU;2-R
Abstract
Various yeast and mould strains were tested in the reduction of alpha- acetyl-gamma-butyrolactone. -(3R,1'R)-alpha-(Hydroxyethyl)-gamma-butyr olactone 2 and anti-(3R,1'S) isomer 3 were obtained enantiomerically p ure. Good enantiomeric excesses are described for the corresponding en antiomers.