Characterization of echovirus 25 (ECV 25) in the VP1/2A gene junction region - Brief Report

Authors
Kunkel, U Schreier, E
Citation
U. Kunkel et E. Schreier, Characterization of echovirus 25 (ECV 25) in the VP1/2A gene junction region - Brief Report, ARCH VIROL, 144(11), 1999, pp. 2253-2258
Citations number
9
Categorie Soggetti
Microbiology
Journal title
ARCHIVES OF VIROLOGY
ISSN journal
03048608 → ACNP
Volume
144
Issue
11
Year of publication
1999
Pages
2253 - 2258
Database
ISI
SICI code
0304-8608(1999)144:11<2253:COE2(2>2.0.ZU;2-Q
Abstract
Genetic relationships among echovirus type 25 (ECV 25) isolates associated with aseptic meningitis in Germany 1997/98 and a 40-year-old ECV 25 prototy pe strain were investigated using RT-PCR and direct sequencing the VP1/2A g ene junction region. Sequences were compared to each other and to nonpolio enterovirus representatives (phylogenetic analysis). The analysis indicated that the sequences of recent isolates have drifted over time distinctly aw ay from the prototype strain sequence. Genetic drift may change biological features of isolates possibly leading to new antigenic variants.