BLOCK OF HFS-INDUCED LTP IN THE DENTATE GYRUS BY 1S,3S-ACPD - FURTHEREVIDENCE AGAINST LTP AS A MODEL FOR LEARNING

WE have previously shown that block of high-frequency stimulation (HFS ) induced long-term potentiation (LTP) of synaptic transmission in are a CA1 by (1S,3S)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3S-ACPD ; 5 mu l of a 20 mM solution), an agonist at group II metabotropic glu tamate receptors, did not prevent animals from learning a spatial task . Here we show that the same dose of 1S,3S-ACPD also blocked the induc tion of HFS-induced LTP of the slope of the excitatory postsynaptic po tential and of the amplitude of the population spike in the dentate gy rus. We conclude that HFS-induced LTP in the dentate gyrus is not a go od model for memory formation.