Disproportional body growth in female estrogen receptor-alpha-inactivated mice

Citation
O. Vidal et al., Disproportional body growth in female estrogen receptor-alpha-inactivated mice, BIOC BIOP R, 265(2), 1999, pp. 569-571
Citations number
11
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN journal
0006291X → ACNP
Volume
265
Issue
2
Year of publication
1999
Pages
569 - 571
Database
ISI
SICI code
0006-291X(19991119)265:2<569:DBGIFE>2.0.ZU;2-6
Abstract
Estrogens play an important role in the regulation of longitudinal bone gro wth in man, as demonstrated by recent descriptions of individuals with estr ogen insensitivity or aromatase deficiency. Two estrogen receptors, ER alph a and ER beta, have been cloned. The aim of the present study was to invest igate the function of ER alpha in the regulation of body growth and skeleta l growth. Adult female mice with inactivated ER alpha (ER alpha-/-) demonst rated an increased body weight compared with wild-type mice (114% of contro l). However, the length of the appendicular skeleton was decreased in adult ER alpha-/- mice (femur 93% of control). In contrast, the axial skeleton w as normal (crown-rump length 98% of control). The decreased growth of the a ppendicular skeleton was associated with decreased serum levels of IGF-I (7 7% of control), indicating that the GH/IGF-I axis may be involved in the de creased longitudinal bone growth seen in female ER alpha-/- mice. (C) 1999 Academic Press.