CHEMOENZYMATIC SYNTHESIS OF CHIRAL BETA-AZIDOALCOHOLS - APPLICATION TO THE PREPARATION OF CHIRAL AZIRIDINES AND AMINOALCOHOLS

Authors
BESSE P VESCHAMBRE H CHENEVERT R DICKMAN M
Citation
P. Besse et al., CHEMOENZYMATIC SYNTHESIS OF CHIRAL BETA-AZIDOALCOHOLS - APPLICATION TO THE PREPARATION OF CHIRAL AZIRIDINES AND AMINOALCOHOLS, Tetrahedron : asymmetry, 5(9), 1994, pp. 1727-1744
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
5
Issue
9
Year of publication
1994
Pages
1727 - 1744
Database
ISI
SICI code
0957-4166(1994)5:9<1727:CSOCB->2.0.ZU;2-Q
Abstract
From the microbiological reduction of 3-azido-2-octanone, 3-azido-4-ph enyl-2-butanone and 1-azido-1-phenyl-2-propanone, homochiral isomers o f the corresponding beta-azidoalcohols were prepared. These ''alpha-bi chiral'' synthons were used to prepare all the stereoisomers of 2-meth yl-3-n-pentylaziridine and 2-methyl-3-benzylaziridine and some homochi ral aminoalcohols.