Vitamin D receptor genotype and breast cancer in Latinas (United States)

Objective: Polymorphism in the vitamin D receptor (VDR) gene has been assoc iated with variation in bone mineral density and with prostate cancer risk. The purpose of this study was to determine whether polymorphism in the VDR gene may also influence breast cancer risk. Methods: Polymorphisms in the 5' and 3' ends of the VDR gene were genotyped for 143 Latina women with breast cancer and 300 cohort controls. Results: Both the BsmI and poly-A polymorphisms in the 3' end of the VDR ge ne were associated with breast cancer risk, with a trend for increasing ris k with increasing number of BsmI B alleles or short (S) poly-A alleles. Com pared to subjects having two long poly-A alleles (genotype LL), odds ratios (and 95% confidence intervals) were 1.5 (1.0-2.3) and 3.2 (1.5-6.9) for su bjects having genotypes SL and SS, respectively. Compared to BsmI genotype bb, odds ratios (and 95% confidence intervals) were 1.6 (1.1-2.5) and 2.2 ( 1.0-4.7) for genotypes Bb and BB respectively. The start codon polymorphism , FokI, was not associated with breast cancer risk. Conclusion: These results suggest that polymorphic variation in or near the 3' end of the VDR gene influences breast cancer risk in Latina women.