General acid catalysed hydrolysis of beta-sultams involves nucleophilic catalysis

Authors
Baxter, NJ Laws, AP Rigoreau, LJH Page, MI
Citation
Nj. Baxter et al., General acid catalysed hydrolysis of beta-sultams involves nucleophilic catalysis, CHEM COMMUN, (23), 1999, pp. 2401-2402
Citations number
13
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
23
Year of publication
1999
Pages
2401 - 2402
Database
ISI
SICI code
1359-7345(1999):23<2401:GACHOB>2.0.ZU;2-O
Abstract
The hydrolysis of the four-membered ring sulfonamide N-benzyl beta-sultam i s catalysed by carboxylic acids, which is attributed to specific acid-nucle ophilic catalysis with the intermediate formation of a mixed anhydride whic h can be trapped with aniline.