Diastereoselective aldol reaction of alpha-bromo ketones with aliphatic aldehydes by using titanium(II) chloride and copper

Authors
Mukaiyama, T Kagayama, A Igarashi, K Shiina, I
Citation
T. Mukaiyama et al., Diastereoselective aldol reaction of alpha-bromo ketones with aliphatic aldehydes by using titanium(II) chloride and copper, CHEM LETT, (11), 1999, pp. 1157-1158
Citations number
12
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY LETTERS
ISSN journal
03667022 → ACNP
Issue
11
Year of publication
1999
Pages
1157 - 1158
Database
ISI
SICI code
0366-7022(199911):11<1157:DAROAK>2.0.ZU;2-O
Abstract
Highly diastereoselective aldol reaction of alpha-bromo ketones with alipha tic aldehydes was successfully carried out by using titanium(II) chloride a nd copper in dichloromethane at low temperature. Similarly, Reformatsky-typ e reaction of a-bromo thioester with aliphatic aldehydes was promoted under mild conditions to afford P-hydroxy thioesters in good to moderate yields.