A novel universal detection system for capillary chip electrophoresis utili
zing surface plasmon resonance (SPR) detection was developed. Nafion tube w
as used as a septum to draw electric current outside the flow without gener
ating any bubble in the capillary channel. Polydimethyl siloxane as a capil
lary chip could easily attained this setup. We could successfully observe s
mall change in refractive index by SPR under elctroosmotic flow.