Background-Valve regurgitation has been associated with dexfenfluramine, bu
t its prevalence and severity are uncertain. Additional factors that may co
ntribute to valve regurgitation in patients exposed to this drug are poorly
understood.
Methods and Results-Echocardiography was performed on subjects recruited fr
om 26 prescribing sites in 15 states. The total sample of 412 subjects incl
uded 172 dexfenfluramine patients and 172 unexposed controls matched for ag
e, sex, and body mass index and 68 unmatched subjects meeting the same entr
y criteria (51 dexfenfluramine patients and 17 controls). Mean treatment du
ration was 6.9 months; mean interval from treatment discontinuation to echo
cardiogram was 8.5 months. Each echocardiogram was interpreted independentl
y by 3 echocardiographers, FDA-grade regurgitation (at least mild aortic re
gurgitation or at least moderate mitral regurgitation) was significantly mo
re frequent in dexfenfluramine patients (7.6% versus 2.1% for controls; P=0
.01; odds ratio, 3.82). This difference was primarily due to more frequent
mild aortic regurgitation in dexfenfluramine patients (6.3% versus 1.6% in
controls; P<0.02; odds ratio, 4.15). No differences were found in sclerosis
or mobility for either the aortic or mitral valve. Factors independently r
elated to FDA-grade regurgitation or any grade of aortic regurgitation were
older age, higher diastolic blood pressure at the time of echocardiography
, and shorter time from drug discontinuation to echocardiogram.
Conclusions-Dexfenfluramine use is associated with an increase in the preva
lence of abnormal valve regurgitation. Age and blood pressure may also affe
ct the prevalence of regurgitation. Dexfenfluramine-related valve regurgita
tion may regress after drug discontinuation.