A new methodology for the synthesis of polyhydroxylated azetidinic alkaloids.

Authors
Beauhaire, J Ducrot, PH
Citation
J. Beauhaire et Ph. Ducrot, A new methodology for the synthesis of polyhydroxylated azetidinic alkaloids., CR AC S IIC, 2(9-10), 1999, pp. 477-482
Citations number
33
Categorie Soggetti
Chemistry
Journal title
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE II FASCICULE C-CHIMIE
ISSN journal
13871609 → ACNP
Volume
2
Issue
9-10
Year of publication
1999
Pages
477 - 482
Database
ISI
SICI code
1387-1609(199909/10)2:9-10<477:ANMFTS>2.0.ZU;2-6
Abstract
This paper deals with a new methodology for the synthesis of the polyhydrox ylated azetidinic alkaloids encountered in the penaresidin and penazetidin family using the previously described epoxide 6. The main feature of this s ynthesis lies in the absence of amine and/or hydroxyl protection/deprotecti on sequences usually encountered in the last steps of the synthesis devoted to the heterocycle ring closure. (C) 1999 Academie des sciences/Editions s cientifiques et medicales Elsevier SAS.