Genetic dissection of gustatory sensitivity to bitterness (sucrose octaacetate) in mice

Authors
Le Roy, I Pager, J Roubertoux, PL
Citation
I. Le Roy et al., Genetic dissection of gustatory sensitivity to bitterness (sucrose octaacetate) in mice, CR AC S III, 322(10), 1999, pp. 831-836
Citations number
15
Categorie Soggetti
Multidisciplinary,"Experimental Biology
Journal title
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES
ISSN journal
07644469 → ACNP
Volume
322
Issue
10
Year of publication
1999
Pages
831 - 836
Database
ISI
SICI code
0764-4469(199910)322:10<831:GDOGST>2.0.ZU;2-6
Abstract
Genes implicated in consumption of a bitter corn pou nd, sucrose octaacetat e (SOA), were investigated using a full genomic scanning strategy. For a 0. 1 mM concentration, two QTL reached 5.8 and 6.5 lod scores on chromosomes 2 (77 cM) and 11 (14 cM), respectively. For a 1 mM concentration, the Soa li nkage on chromosome 6 (58 cM, lod score 9.4) was replicated, and another QT L was found on chromosome 19 (15 cM, lod score 3.2). Candidacy of previousl y identified genes in the close vicinity of the peak of the QTL was examine d. (C) 1999 Academie des sciences / Editions scientifiques et medicales Els evier SAS.