Mapping autoimmunity genes

Citation
Mm. Griffiths et al., Mapping autoimmunity genes, CURR OP IM, 11(6), 1999, pp. 689-700
Citations number
78
Categorie Soggetti
Immunology
Journal title
CURRENT OPINION IN IMMUNOLOGY
ISSN journal
09527915 → ACNP
Volume
11
Issue
6
Year of publication
1999
Pages
689 - 700
Database
ISI
SICI code
0952-7915(199912)11:6<689:MAG>2.0.ZU;2-T
Abstract
Rat and mouse models for the major human autoimmune/inflammatory diseases a re under intense genetic scrutiny. Genome-wide linkage studies reveal that each model is regulated by multiple genetic loci, Many of these loci coloca lize to homologous genomic regions associated with several different autoim mune diseases of mice, rats and humans. Candidate genes are being identifie d, Polymorphic alleles associated with these chromosomal segments may repre sent predisposing genetic elements common to a number of human diseases wit h very different clinical presentations.