Lack of morphine-induced dopamine release in the nucleus accumbens of cannabinoid CB1 receptor knockout mice

Authors
Mascia, MS Obinu, MC Ledent, C Parmentier, M Bohme, GA Imperato, A Fratta, W
Citation
Ms. Mascia et al., Lack of morphine-induced dopamine release in the nucleus accumbens of cannabinoid CB1 receptor knockout mice, EUR J PHARM, 383(3), 1999, pp. R1-R2
Citations number
7
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN journal
00142999 → ACNP
Volume
383
Issue
3
Year of publication
1999
Pages
R1 - R2
Database
ISI
SICI code
0014-2999(19991103)383:3<R1:LOMDRI>2.0.ZU;2-C
Abstract
Morphine (10 and 20 mg/kg, s.c.) does not modify dopamine release in the nu cleus accumbens of cannabinoid CB1 knock-out mice under conditions where it dose-dependently stimulates the release of dopamine in the corresponding w ild-type mice. These results demonstrate that cannabinoid CB1 receptors, re gulate mesolimbic dopaminergic transmission in brain areas known to be invo lved in the reinforcing effects of morphine. (C) 1999 Elsevier Science B.V. All rights reserved.