Lipoprotein lipase, a key role in atherosclerosis?

Lipoprotein lipase (LPL) plays a central role in lipid metabolism and trans port by catalysing the hydrolysis of triacylglycerol-rich lipoproteins. The importance of LPL expressed by the adipose tissue and muscles in the provi sion of non-esterified fatty acids and 2-monoacylglycerol for tissue utilis ation is well established, However, recent studies on LPL expressed by cell s of the vascular wall, particularly macrophages, have identified additiona l actions of the enzyme that contribute to the promotion of foam cell forma tion and atherosclerosis, This review deals with the role of LPL in atheros clerosis, and its regulation by mediators that are known to be present in t he lesion. (C) 1999 Federation of European Biochemical Societies.