Quantitative trait locus detection using combined linkage/disequilibrium analysis

Authors
Almasy, L Williams, JT Dyer, TD Blangero, J
Citation
L. Almasy et al., Quantitative trait locus detection using combined linkage/disequilibrium analysis, GENET EPID, 17, 1999, pp. S31-S36
Citations number
6
Categorie Soggetti
Molecular Biology & Genetics
Journal title
GENETIC EPIDEMIOLOGY
ISSN journal
07410395 → ACNP
Volume
17
Year of publication
1999
Supplement
1
Pages
S31 - S36
Database
ISI
SICI code
0741-0395(1999)17:<S31:QTLDUC>2.0.ZU;2-Z
Abstract
We describe an extension of the variance component linkage method that augm ents identity-by-descent information from relatives with identity-by-state information from unrelated individuals, exploiting disequilibrium to facili tate fine mapping of quantitative trait loci. An advantage of the combined linkage/disequilibrium test is that it detects association only in the pres ence of linkage and is not biased by population stratification. (C) 1999 Wi ley-Liss, Inc.