Gp. Page et al., Genome scans for genetic predisposition to alcoholism by use of transmission disequilibrium test analyses, GENET EPID, 17, 1999, pp. S277-S281
We report the results of the analysis of three measures of alcoholism and s
ix associated symptoms using transmission disequilibrium (TDT) analysis on
data from the Collaborative Study on the Genetics of Alcoholism data set. I
mplementation of identity-by-state (IBS) routines for error checking reveal
ed 10 reported full siblings that were rejected as a full sibling to all of
their purported full siblings with p < 0.05. TDT analysis revealed two loc
i with significant transmission disequilibrium (p < 0.001) on chromosomes 1
and 7. Analysis by parental origin found alleles at three loci displaying
significant disequilibrium in the transmission of the paternal alleles for
at least three of the nine tested traits. These loci are on chromosomes 6,
9, and 13. Analyses of Caucasian families alone and the use of a single aff
ected individual from each family also yielded significant results for the
loci on chromosomes 6, 9, and 13. (C) 1999 Wiley-Liss, Inc.