Association and linkage analysis of ICD-10 diagnosis for alcoholism

Authors
Tiwari, HK Zhu, XF Elston, RC Shu, YY George, V
Citation
Hk. Tiwari et al., Association and linkage analysis of ICD-10 diagnosis for alcoholism, GENET EPID, 17, 1999, pp. S343-S347
Citations number
14
Categorie Soggetti
Molecular Biology & Genetics
Journal title
GENETIC EPIDEMIOLOGY
ISSN journal
07410395 → ACNP
Volume
17
Year of publication
1999
Supplement
1
Pages
S343 - S347
Database
ISI
SICI code
0741-0395(1999)17:<S343:AALAOI>2.0.ZU;2-P
Abstract
We analyzed the GAW11 data on alcoholism provided by the Collaborative Stud y on the Genetics of Alcoholism (COGA) using an extension of a new test of linkage and association for quantitative traits developed by George et al. [1999]. This method determines linkage between marker loci and quantitative traits, when allelic association is present between the trait and marker l oci, by regressing the disease trait on the parental transmission of the al lele of interest. We found no strong evidence of linkage to any markers. Ho wever, we found several markers suggestive of possible linkage that may des erve further investigation. (C) 1999 Wiley-Liss, Inc.