We tested a new computer program, LOKI, that implements a reversible jump M
arkov chain Monte Carlo (MCMC) technique for segregation and linkage analys
is. Our objective was to determine whether this software, designed for use
with continuously distributed phenotypes, has any efficacy when applied to
the discrete disease states of the simulated data from the Mordor data from
GAW Problem 1. Although we were able to identify the genomic location for
two of the three quantitative trait loci by repeated application of the sof
tware, the MCMC sampler experienced significant mixing problems indicating
that the method, as currently formulated in LOKI, was not suitable for the
discrete phenotypes in this data set. ((C)) 1999 Wiley-Liss, Inc.