Environmental covariates: Effects on the power of sib-pair linkage methods

Authors
Mandal, DM Sorant, AJM Pugh, EW Marcus, SE Klein, AP Mathias, RA O'Neill, J Temiyakarn, LF Wilson, AF Bailey-Wilson, JE
Citation
Dm. Mandal et al., Environmental covariates: Effects on the power of sib-pair linkage methods, GENET EPID, 17, 1999, pp. S643-S648
Citations number
8
Categorie Soggetti
Molecular Biology & Genetics
Journal title
GENETIC EPIDEMIOLOGY
ISSN journal
07410395 → ACNP
Volume
17
Year of publication
1999
Supplement
1
Pages
S643 - S648
Database
ISI
SICI code
0741-0395(1999)17:<S643:ECEOTP>2.0.ZU;2-P
Abstract
The effect of inclusion of environmental risk factors on the power of sib-p air linkage methods was tested for a qualitative trait. It was found that i nclusion of an environmental variable did not increase the power of the Has eman-Elston (H-E) sib-pair nonparametric linkage analysis test. However, a significant increase in power was observed for both the H-E and affected-si b-pair tests, even in small samples, when persons unexposed to the environm ental risk factor were coded as unknown. (C) 1999 Wiley-Liss, Inc.