PATHOGENESIS AND MANAGEMENT OF BONE-LESIONS IN MULTIPLE-MYELOMA

Authors
BATAILLE R MANOLAGAS SC BERENSON JR
Citation
R. Bataille et al., PATHOGENESIS AND MANAGEMENT OF BONE-LESIONS IN MULTIPLE-MYELOMA, Hematology/oncology clinics of North America, 11(2), 1997, pp. 349
Citations number
80
Categorie Soggetti
Oncology,Hematology
Journal title
Hematology/oncology clinics of North America → ACNP
ISSN journal
08898588
Volume
11
Issue
2
Year of publication
1997
Database
ISI
SICI code
0889-8588(1997)11:2<349:PAMOBI>2.0.ZU;2-D
Abstract
Osteolytic lesions are among the hallmarks of multiple myeloma (MM). O n the other hand, they are rare in B cell malignancies other than MM. Data have shown a close relationship between myeloma cell. growth fact ors and factors involved in the occurrence of bone lesions in MM. Biop hosphonates, which are potent inhibitors of bone resorption to control MM-induced hypercalcemia, are of interest due to their ability to slo w the progression of MM bone disease.