Sera from three separate healthy population cohorts were used to determine
the incidence of group C rotavirus infections in 1,356 South Africans. Usin
g an enzyme-linked immunosorbent assay based on a recombinant group C rotav
irus VP6 protein, the total percent positivity was found to be 34.4% (range
, 33 to 38%), with almost half of the population infected after the age of
20 years.