Biocompatibility of an adhesive system and 2-hydroxyethylmethacrylate

The aim of the study was to evaluate the biocompatibility of an adhesive sy stem and a resin component when implanted into connective tissue of rats. F orty sponges embedded in both materials: Scotchbond MP (SBMP/3M - Group A) and 2 - hydroxyethyl-methacrylate (HEMA - Group B), were implanted into dor sal connective tissue of 20 animals. After 7, 15, 30, or 60 days of the imp lantation, the animals were sacrificed; implant sites were excised and imme rsed for 24 hours in Kamovisky's fixative. The samples were processed under routine histologic technique, being stained with H & E. Histological evalu ation showed that both materials promoted at 7 days intense inflammatory re sponse with predominance of neutrophils and macrophages. The intense connec tive reaction was replaced for fibroblastic proliferation associated with m acrophages and foreign body giant cells over time. The persistent moderate inflammatory reaction adjacent to scattered fragments of materials was grea ter to HEMA than to the SBMP. Both experimental materials did not show acce ptable biocompatibility with connective tissue of rats in spite of allowing an evident connective tissue healing.