Protoporphyrin IX fluorescence from the plasma of tumor-implanted mouse

MH134 mouse tumor cells were implanted in C3H/HeN mice and the metabolic le vel of protoporphyrin IX from the tumor-implanted mice was studied. The flu orescence intensity from the plasma of tumor-implanted mice was obtained du ring the tumor development and the spectral ratio was used to determine the stage. The experimental data of metabolic level was analyzed and fitted to a function L(t) = L-0 + L-max[1 - ((t - T/2)/(T/2))(2)], which described t he tumor development and may be used to estimate the stage of disease in th e tumor-implanted mice. (C) 1999 Elsevier Science B.V. All rights reserved.