PRIMARY STRUCTURE OF THE PROPEPTIDE AND FACTOR VIII-BINDING DOMAIN OFBOVINE VON-WILLEBRAND-FACTOR

A 2811 base-pair cDNA, encoding the amino-terminal part of the bovine pre-pro-von Willebrand factor, was characterized and sequenced. The de duced amino acid sequence shares significant homology with the human v on Willebrand antigen II and the amino-terminal part of the factor VII I-binding domain of von Willebrand factor. In contrast to human, there is no RGD motif in the bovine von Willebrand antigen II. High levels of Cys, characteristic of D domains, are also found in bovine and the Cys position is markedly conserved between the two species.