Detection of endometrial adenocarcinoma in two asymptomatic postmenopausalwomen receiving tamoxifen - A report of two cases

BACKGROUND: Tamoxifen has been linked to an increased risk for the developm ent of endometrial adenocarcinoma. The majority of these carcinomas present with postmenopausal bleeding. The current standard is to undertake samplin g only after the onset of bleeding. CASES: Two cases illustrate the utility of transvaginal saline infusion son ohysterography (TVS/SIS) in the detection of endometrial carcinoma prior to the onset of bleeding. CONCLUSION: Annual TVS/SIS may be useful for screening asymptomatic, tamoxi fen-exposed patients with a uterus in situ and is likely to be more accepta ble to such patients than annual biopsies.