Synthetic studies on the glycosylation of the base residues of inosine anduridine

Authors
De Napoli, L Di Fabio, G Messere, A Montesarchio, D Piccialli, G Varra, M
Citation
L. De Napoli et al., Synthetic studies on the glycosylation of the base residues of inosine anduridine, J CHEM S P1, (23), 1999, pp. 3489-3493
Citations number
26
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
0300922X → ACNP
Issue
23
Year of publication
1999
Pages
3489 - 3493
Database
ISI
SICI code
0300-922X(1999):23<3489:SSOTGO>2.0.ZU;2-Z
Abstract
Ribosylation and glucosylation of the base residues of inosine and uridine have been efficiently achieved using Mitsunobu reaction, leading to the N-1 and 6-O-glycosylinosine and N-3-glycosyluridine derivatives, all with beta configuration at the glycosidic carbon. The unprecedented 5-amino-1-(beta- D-ribofuranosyl)imidazole-4-[ N-(beta-D-glucopyranosyl)carboxamide] has als o been synthesised.