Aryl H-phosphonates. Part 11. Synthetic and P-31 NMR studies on the formation of aryl nucleoside H-phosphonates

Authors
Cieslak, J Szymczak, M Wenska, M Stawinski, J Kraszewski, A
Citation
J. Cieslak et al., Aryl H-phosphonates. Part 11. Synthetic and P-31 NMR studies on the formation of aryl nucleoside H-phosphonates, J CHEM S P1, (22), 1999, pp. 3327-3331
Citations number
24
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
0300922X → ACNP
Issue
22
Year of publication
1999
Pages
3327 - 3331
Database
ISI
SICI code
0300-922X(1999):22<3327:AHP1SA>2.0.ZU;2-1
Abstract
The formation of aryl H-phosphonate diesters from the corresponding nucleos ide 3'-H-phosphonates and various phenols was investigated in detail using P-31 NMR spectroscopy. The major reaction pathways of aryl nucleoside H-pho sphonates under different experimental conditions have been identified and a general method for a clean and efficient generation of these valuable syn thetic intermediates was developed.