On the toxicity of phenols to fast growing cells. A QSAR model for a radical-based toxicity

The cytotoxicities of a series of simple phenols as well as estrogenic phen ols such as octyl and nonyl phenols, Bisphenol A, diethylstilbestrol, estra diol, estriol, equilin and equilenin were studied in a fast growing murine leukemia cell line. The use of calculated homolytic bond dissociation energ ies (BDE) as the electronic parameter led to the development of a Quantitat ive Structure-Activity Relationship model with superior results; one which established the importance of relatively low BDE values in enhancing toxici ty to rapidly multiplying cells. The correlation equation that emerged is a s follows: log 1/ C = -0.19BDE + 0.21 log P + 3.11. It suggests that toxici ty is closely related to mostly homolytic cleavage of the phenolic O-H bond and overall hydrophobicity of the phenol.