Expression of Frzb-1 during chick development

Citation
D. Duprez et al., Expression of Frzb-1 during chick development, MECH DEVEL, 89(1-2), 1999, pp. 179-183
Citations number
12
Categorie Soggetti
Cell & Developmental Biology
Journal title
MECHANISMS OF DEVELOPMENT
ISSN journal
09254773 → ACNP
Volume
89
Issue
1-2
Year of publication
1999
Pages
179 - 183
Database
ISI
SICI code
0925-4773(199912)89:1-2<179:EOFDCD>2.0.ZU;2-M
Abstract
We cloned the chick homolog of Xenopus and mouse Frzb-1, a secreted Wnt ant agonist and performed in situ hybridisations to determine the pattern of cF rzb-1 expression in the developing chick embryo. At early stages, cFrzb-1 t ranscripts are located exclusively in the ectodermal layer corresponding to the neural plate. The labelling continues in the neural tube, but is alway s excluded from the floor plate, cFrzb-1 mRNA is expressed by migrating cep halic and truncal neural crest cells. Later, cFrzb-1 transcripts are found in a subset of neural crest derivatives such as cephalic cartilage, nerves and spinal ganglia. In addition to ectodermal derivatives, cFrzb-1 transcri pts were also observed in mesodermal derivatives such as vertebral and limb cartilage, the adrenal cortex, the gonads, and a subpopulation of blood ce lls. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.