THERAPEUTIC AND IMAGING CAPACITY OF TUMOR-LOCALIZING RADIOSENSITIVE MN-PORPHYRIN ON SCCVII TUMOR-BEARING C3H HE MICE/

We synthesized a radiosensitizer KADTF, consisting of a hypoxic radios ensitizer, KU2280, bound to the side chain group of Mn-metalloporphyri n, which accumulates in tumor tissue, In the in vitro colony-forming a ctivity test using HeLa cells, KADTF enhanced the effect of radiation under hypoxic conditions, Radiation therapy at 20 Gy, 1.5 h after infu sion of KADTF (0.15 mM/kg), inhibited tumor growth more markedly than did a single radiation treatment, A clear tumor MR Images of the SCCVI I tumor was obtained at 1.5 h after administration of KADTF (0.1 mM/kg ).