Effects of atypical antipsychotic drugs vs. haloperidol on expression of beat shock protein in the discrete brain regions of phencyclidine-treated rats

Haloperidol augmented a trend of an increase in the heat shock protein (hsp 70) mRNA levels induced by phencyclidine (PCP) in rat medial prefrontal cor tex, nucleus accumbens and striatum, while the atypical antipsychotic drugs such as clozapine, olanzapine and risperidone decreased it. When administe red alone, clozapine, but not haloperidol, decreased hsp70 mRNA levels. Hal operidol and the atypical antipsychotic drugs may thus have differential ef fects on hsp70 expression in some brain regions of PCP-treated rats. (C) 19 99 Elsevier Science B.V. All rights reserved.