Alterations in spore production in Trichophyton rubrum treated in vitro with 1-amino-6-methyl-4-phenylpyrazolo[3,4-d]-1,2,3-triazole

The effects of the newly synthesized triazole, 1-amino-6-methyl-4-phenylpyr azolo[3,4-6]-1,2,3-triazole (V5), on the dermatophyte Trichophyton rubrum w ere tested. Optical and electron microscopy showed that the treatment suppr essed the various forms of saprophytic conidia, induced the formation of ch lamydospores and accelerated the formation of arthroconidia. This new triaz ole did not reveal any fungistatic or fungicidal activity and could not be considered as an antifungal substance.