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The DNA sequence of human chromosome 22

Authors

Dunham, I Shimizu, N Roe, BA Chissoe, S Dunham, I Hunt, AR Collins, JE Bruskiewich, R Beare, DM Clamp, M Smink, LJ Ainscough, R Almeida, JP Babbage, A Bagguley, C Balley, J Barlow, K Bates, KN Beasley, O Bird, CP Blakey, S Bridgeman, AM Buck, D Burgess, J Burrill, WD Burton, J Carder, C Carter, NP Chen, Y Clark, G Clegg, SM Cobley, V Cole, CG Collier, RE Connor, RE Conroy, D Corby, N Coville, GJ Cox, AV Davis, J Dawson, E Dhami, PD Dockree, C Dodsworth, SJ Durbin, RM Ellington, A Evans, KL Fey, JM Fleming, K French, L Garner, AA Gilbert, JGR Goward, ME Grafham, D Griffiths, MN Hall, C Hall, R Hall-Tamlyn, G Heathcott, RW Ho, S Holmes, S Hunt, SE Jones, MC Kershaw, J Kimberley, A King, A Laird, GK Langford, CF Leversha, MA Lloyd, C Lloyd, DM Martyn, ID Mashreghi-Mohammadi, M Matthews, L McCann, OT McClay, J McLaren, S McMurray, AA Milne, SA Mortimore, BJ Odell, CN Pavitt, R Pearce, AV Pearson, D Phillimore, BJ Phillips, SH Plumb, RW Ramsay, H Ramsey, Y Rogers, L Ross, MT Scott, CE Sehra, HK Skuce, CD Smalley, S Smith, ML Soderlund, C Spragon, L Steward, CA Sulston, JE Swann, RM Vaudin, M Wall, M Wallis, JM Whiteley, MN Willey, D Williams, L Williams, S Williamson, H Wilmer, TE Wilming, L Wright, CL Hubbard, T Bentley, DR Beck, S Rogers, J Shimizu, N Minoshima, S Kawasaki, K Sasaki, T Asakawa, S Kudoh, J Shintani, A Shibuya, K Yoshizaki, Y Aoki, N Mitsuyama, S Roe, BA Chen, F Chu, L Crabtree, J Deschamps, S Do, A Do, T Dorman, A Fang, F Fu, Y Hu, P Hua, A Kenton, S Lai, H Lao, HI Lewis, J Lewis, S Lin, SP Loh, P Malaj, E Nguyen, T Pan, H Phan, S Qi, S Qian, Y Ray, L Ren, Q Shaull, S Sloan, D Song, L Wang, Q Wang, Y Wang, Z White, J Willingham, D Wu, H Yao, Z Zhan, M Zhang, G Chissoe, S Murray, J Miller, N Minx, P Fulton, R Johnson, D Bemis, G Bentley, D Bradshaw, H Bourne, S Cordes, M Du, Z Fulton, L Goela, D Graves, T Hawkins, J Hinds, K Kemp, K Latreille, P Layman, D Ozersky, P Rohlfing, T Scheet, P Walker, C Wamsley, A Wohldmann, P Pepin, K Nelson, J Korf, I Bedell, JA Hillier, L Mardis, E Waterston, R Wilson, R Emanuel, BS Shaikh, T Kurahashi, H Saitta, S Budarf, ML McDermid, HE Johnson, A Wong, ACC Morrow, BE Edelman, L Kim, UJ Shizuya, H Simon, MI Dumanski, JP Peyrard, M Kedra, D Seroussi, E Fransson, I Tapia, I Bruder, CE O'Brien, KP

Citation

I. Dunham et al., The DNA sequence of human chromosome 22, NATURE, 402(6761), 1999, pp. 489-495

Citations number

Categorie Soggetti

Multidisciplinary,Multidisciplinary,Multidisciplinary

Journal title

NATURE

ISSN journal

00280836 → ACNP

Volume

402

Issue

6761

Year of publication

1999

Pages

489 - 495

Database

ISI

SICI code

0028-0836(199912)402:6761<489:TDSOHC>2.0.ZU;2-U

Abstract

Knowledge of the complete genomic DNA sequence of an organism allows a syst ematic approach to defining its genetic components. The genomic sequence pr ovides access to the complete structures of all genes, including those with out known function, their control elements, and, by inference, the proteins they encode, as well as all other biologically important sequences. Furthe rmore, the sequence is a rich and permanent source of information for the d esign of further biological studies of the organism and for the study of ev olution through cross-species sequence comparison. The power of this approa ch has been amply demonstrated by the determination of the sequences of a n umber of microbial and model organisms, The next step is to obtain the comp lete sequence of the entire human genome. Here we report the sequence of th e euchromatic part of human chromosome 22. The sequence obtained consists o f 12 contiguous segments spanning 33.4 megabases, contains at least 545 gen es and 134 pseudogenes, and provides the first view of the complex chromoso mal landscapes that will be found in the rest of the genome.