Red nucleus neurons of Bcl-2 over-expressing mice are protected from cell death induced by axotomy

Authors
Zhou, LQ Connors, T Chen, DF Murray, M Tessler, A Kambin, P Saavedra, RA
Citation
Lq. Zhou et al., Red nucleus neurons of Bcl-2 over-expressing mice are protected from cell death induced by axotomy, NEUROREPORT, 10(16), 1999, pp. 3417-3421
Citations number
25
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
09594965 → ACNP
Volume
10
Issue
16
Year of publication
1999
Pages
3417 - 3421
Database
ISI
SICI code
0959-4965(19991108)10:16<3417:RNNOBO>2.0.ZU;2-U
Abstract
THE Bcl-2 proto-oncogene regulates apoptosis and prevents cell death. We st udied the effect of Bcl-2 gene over-expression on the survival of axotomize d red nucleus,(RN) neurons after unilateral hemisection at cervical segment 4/5 (C4/5) in mice. Seventy-five percent of RN neurons survived in Bcl-2 o ver-expressing mice 1 or 2 months after surgery compared with only 55% of R N neurons in wild-type mice. However, Bcl-2 gene over-expression does not p revent lesion-induced shrinkage of RN neurons. NeuroReport 10:3417-3421 (C) 1999 Lippincott Williams & Wilkins.