Synthesis of tumour affine Yb-169-and Y-90-porphyrin complexes and animal experiments with different Yb-169-porphyrins

Aim: It should be shown, that it is possible to insert radioactive isotopes of Yb and Y into some selected porphyrins. Besides, first informations abo ut the biodistribution of Yb-169-por-phyrin-complexes should be obtained. M ethods: Carrier added radioactive isotopes were used for the synthesis of t he metal porphyrin complexes. The animal experiments were done with mamma c arcinoma bearing mice. The activity of the organs was determined 5 and 24 h after i.v. injection in a well counter. Results: Four Yb-169-porphyrin com plexes and Y-90-porphyrin complexes could be synthesized in non-carrier-fre e form. This was verified by absorption spectra, TLC and HPLC. Depending on the complex, the average tumour/background ratios were between 2 and 20. C onclusion: The synthesized radioactive metal-porphyrin complexes showed a c lear tumour-affinity wich could be used for tumour scintigraphy or perhaps therapy if the synthesis is improved (goal: reduction of carrier, other rad ionuclides).