Synthesis of arcyriarubine regioisomers by Pd(0)-catalysis or via lithiated indole derivatives - conformational analysis by semiempirical and X-ray methods

Authors
Mahboobi, S Dove, S Kuhr, S Pongratz, H
Citation
S. Mahboobi et al., Synthesis of arcyriarubine regioisomers by Pd(0)-catalysis or via lithiated indole derivatives - conformational analysis by semiempirical and X-ray methods, PHARMAZIE, 54(11), 1999, pp. 820-827
Citations number
25
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHARMAZIE
ISSN journal
00317144 → ACNP
Volume
54
Issue
11
Year of publication
1999
Pages
820 - 827
Database
ISI
SICI code
0031-7144(199911)54:11<820:SOARBP>2.0.ZU;2-Z
Abstract
Regioisomers of arcyriarubines were synthesized by the reaction of N-protec ted indoles with dibromomaleimide either in the presence of a Pd(0)-catalys t or n-BuLi. Methods for N-alkylation of these bisindolylmaleimides and dep rotection of the indole-N are described. The structure of the bisindolylmal eimide 11 was studied by semiempiric quantum-chemical calculations, the str ucture of its derivative 14b was ascertained by X-ray analysis.