Synthesis of phosphonopeptides containing 1-aminoalkylphosphonic acid

Four phosphonodipeptides containing 1-aminoalkylphosphonate were synthesize d by applying four different coupling methods. One of them was then convert ed into monoacid, ethyl hydrogen 1-(N-acetyl-prolyl)amino-2-phenylethyl pho sphonate. Three phosphonodipeptides containing ethyl 1w-amino-2-phenylethyl phosphonamidate were also prepared by converting phosphono monoacid into ph osphonochloridate and reacting it with amino acid ester. Benzyl ethoxyphosp honyl-glycyl-glycine ethyl ester also was synthesized from ethyl glycylglyc inate and ethyl benzylphosphonochloridate derived from direct chlorination of diethyl benzylphosphonate with phosphorus oxychloride.