A facile one step synthesis of [3-(2-hydrazino-4-thiazolyl) coumarino] dimethyl methines and some 3-substituted-7H-6-(6/8,6,8-substituted-3-coumarino)-s-triazolo[3,4-b][1,3,4]thiadiazines

Some [3-(7-hydrazino-4-thiazolyl) coumarino]dimethyl methine derivatives (I II) have been prepared by the condensation of 3-(2-bromoacetyl)-coumarin an d thiosemicarbazide in acetone. These compounds formation was further confi rmed by the condensation of acetone thiosemicarbazone (I) and p-NN-dimethyl amino benzaldehyde thiosemicarbazone :(II) with 3-(2-bromoacetyl)coumarin in anhydrous ethanol and dimethyl formamide in a two step process. 3-Substi tuted-7H-6-(6 or 8 or 6,8-disubstituted 3-coumarino)-s-triazolo[3, 4-b] [1, 3,4]thiadiazines (V) have also been prepared from simple condensation of ap propriate 4-amino-5-mercapto-1,2, 4-triazole with various 3-(2-bromoacetyl) coumarins in anhydrous ethanol and dimethyl formamide.