Paired studies were conducted in 18 healthy volunteers (9 men, 9 women
) to investigate whether differences in mood and daytime sleepiness in
duced by high-fat-low-carbohydrate (CHO) and low-fat-high-CHO morning
meals;were associated with specific hormonal responses. Plasma insulin
concentrations were significantly higher after low-fat-high-CHO meals
, and cholecystokinin (CCK) concentrations were significantly higher a
fter high-fat-low-CHO meals. Subjects tended to feel more sleepy and l
ess awake 2-3 h after the high-fat-low-CHO meal, and ratings of fatigu
e were significantly greater 3 h after the high-fat-low-CHO meal than
after the low-fat-high-CHO meal. The results of the present study are
consistent with the hypothesis that there is an association between th
e lassitude experienced after a meal and the release of CCK. (C) 1997
Elsevier Science Inc.